Altered levels of interleukin-1 beta and interleukin-1 receptor antagonist in chronic myelogenous leukemia: clinical and prognostic correlates

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Altered levels of interleukin-1 beta and interleukin-1 receptor antagonist in chronic myelogenous leukemia: clinical and prognostic correlates.

We have recently demonstrated that interleukin (IL)-1 beta levels are elevated in advanced chronic myelogenous leukemia (CML) and that IL-1 inhibitors can suppress CML clonogenic growth. To further assess the clinical implications of increased IL-1 beta expression in CML, we analyzed IL-1 beta and IL-1 receptor antagonist (IL-1RA) levels in leukocyte lysates from a series of CML patients and fr...

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Altered Levels of Interleukin-lp and Interleukin-l Receptor Antagonist in Chronic Myelogenous Leukemia: Clinical and Prognostic Correlates

We have recently demonstrated that interleukin (IL)-lp levels are elevated in advanced chronic myelogenous leukemia CML) and that IL-l inhibitors can suppress CML clonogenic growth. To further assess the clinical implications of increased IL-1p expression in CML, we analyzed IL-1p and ILl receptor antagonist (IL-IRA) levels in leukocyte lysates from a series of CML patients and from normal volu...

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ژورنال

عنوان ژورنال: Blood

سال: 1994

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v84.9.3142.3142